What is the antidote to antabuse? - Answered by a verified Doctor. We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Medical. Have medical questions? Ask a doctor online! Connect one-on-one with 0 who will answer your question. A disulfiram-like drug is a drug that causes hypersensitivity to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others. Interesting, I had no idea Disulfiram had implants, there is no antidote other than to get it removed from your body. So you need to speak to a doctor and potentially get some surgery. So you need to speak to a doctor and potentially get some surgery. Disulfiram is a drug used to treat alcoholism by causing an unpleasant reaction to drinking alcohol. Learn about the use of antabuse in treating alcoholism. ED treatment of disulfiram-ethanol reaction (DER) is primarily supportive. No specific antidote has been tested for efficacy in the treatment of DER or acute disulfiram overdose, though fomepizole has the theoretical benefit of blocking ethanol metabolism to acetaldehyde and may be a useful therapy in patients presenting with DER. Causes. Il est provoqué par l'absorption concomitante d'alcool et de certaines substances médicamenteuses, en particulier le disulfirame et le métronidazole. There is no antidote for acute disulfiram overdose, chronic disulfiram overuse, or disulfiram-ethanol reaction. (1, 4) (1, 4) Supportive care with fluids, antiemetics, and antihistamines is the mainstay treatment. Antabuse (disulfiram) blocks an enzyme that is involved in metabolizing alcohol intake. Disulfiram produces very unpleasant side effects when combined with alcohol in the body. Ultimately, disulfiram reduces the rate of oxidation of acetaldehyde, causing a 5- to 10-fold increase in the concentration of acetaldehyde. An increased serum acetaldehyde concentration is thought to be responsible for the unpleasant side effects associated with the disulfiram-ethanol reaction. Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase , which means that many of the effects of a hangover are felt immediately after alcohol is consumed.